What Is VDR?
VDR is a gene which codes for a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene, the rs2228570 (FokI polymorphism), is associated with lower bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern and the temporal on-and-off occupancy of VDRE between the two components. It is also modulated by chromosomal location and binding preferences for certain hormones. Microarray studies of human cells show that over 100 genes have a recognizable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository of data and documents pertinent to legal, business, or other proceedings that have restrictions on viewing and downloading. It is accessed via a central server as well as an extranet connection that is an Internet connection that has restricted access, which allows restricted access to log-in for specific times when users can browse the documents and data.
VDRs are most commonly used by investment banks and businesses involved in mergers or acquisitions. They require an efficient and secure platform to share information with potential buyers or investors in a manner that is transparent, and the process of due diligence could require huge amounts of information. Life science companies also utilize VDRs to store everything from clinical trial results to HIPAA documentation.